Effect of psilocybin on marble burying in ICR mice: role of 5-HT1A receptors and implications for the treatment of obsessive-compulsive disorder

Abstract Preliminary clinical findings, supported by preclinical studies employing behavioral paradigms such as marble burying, suggest that psilocybin may be effective in treating obsessive-compulsive disorder.However, the receptor mechanisms implicated in the putative anti-obsessional effect are not clear.On this background, we set out to explore

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Intrinsically disordered proteins studied by NMR spectroscopy

Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) of complex multi-domain proteins are now identified as a trend topic by the scientific community.NMR constitutes a unique investigation tool to access atom resolved information on their structural and dynamic properties, in isolation or upon interaction with potent

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ECE2 is a prognostic biomarker associated with m6A modification and involved in immune infiltration of lung adenocarcinoma

BackgroundThe targeted therapy for lung cancer relies on prognostic genes and requires further research.No research has been conducted to determine the effect of endothelin-converting enzyme 2 (ECE2) in lung cancer.MethodsWe analyzed the expression of ECE2 in lung adenocarcinoma (LUAD) and normal adjacent tissues and its relationship with clinicopa

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